Antimicrobial cationic peptides

Details Antimicrobial cationic peptides Antimicrobial cationic peptides

1996-12-10

2000-05-02

Prouty, Rebecca E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 530324, 530326, A61K 3800

Patent

active

060572914

ABSTRACT:
A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH.sub.2 --KWKSFIKKLTTAVKKVLTTGLPALIS--COOH (SEQ ID NO:1) and NH.sub.2 --KWKSFIKKLTSAAKKVVTTAKPLISS--COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.

REFERENCES:
patent: 5585353 (1996-12-01), Merrifield et al.
patent: 5593866 (1997-01-01), Hancock et al.
Bowman et al. (1996) GenBank Accession No. W23487.
Brown et al. (1997) GenBank Accession No. W14735.
Brown et al. (1996) GenBank Accession No. W00275.

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