Antimicrobial cationic peptides

Details Antimicrobial cationic peptides Antimicrobial cationic peptides

1995-06-02

1999-03-02

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 514 2, 514 12, A61K 3816

Patent

active

058772740

ABSTRACT:
A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH.sub.2 -KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH.sub.2 -KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2).

REFERENCES:
Piers et al., "The Interaction of a recombinant cecropin/melittin hybrid peptide with the outer membrane of Pseudomonas aeruginosa", Molecular Microbiology, (1994) 12(6), 951-958.
Bessalle et al., "Structure-Function Studies of Amphiphilic Antibacterial Peptides", J. Med. Chem., 1993, 36, 1203-1209.
Piers et al. (1994) Improvement of Outer Membrane-Permeabilizing and Lipopolysaccharide-Binding Activities of an Antimicrobial Cationic Peptide by C-Terminal Modification. Antimicrobial Agents and Chemotherapy. vol. 38, No. 10, pp. 2311-2316, 1994.

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