Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-06-10
1987-04-14
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544347, 435886, C07D24146, C07D40112, C07D40312, A61K 31495
Patent
active
046579095
ABSTRACT:
Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity.
A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.
REFERENCES:
patent: 3359165 (1967-12-01), Bergy
Tipton et al, J.A.C.S., 92, 1425-6 (1970).
Bergy, Chem. Abs., 71, 53512r (1969).
Tipton, Chem. Abs., 76, 126940u (1972).
Bigge Christopher F.
Elslager Edward F.
French James C.
Graham Blanche D.
Hokanson Gerard C.
Berch Mark L.
Janssen Jerry F.
Warner-Lambert & Company
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