Antimicrobial agents and process for their manufacture

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514108, A61K 3166

Patent

active

048206989

ABSTRACT:
Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic microorganisms, such as bacteria, yeasts, viruses, fungi and protozoa, when used together with a pharmaceutically-acceptable carrier. Also disclosed is a method for treating infectious diseases by administering a safe and effective amount of these tetraalkyl ethenylidenebisphosphonates.

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Semmalhack et al., J. Org. Chem. 43(6), pp. 1259-1262 (Mar. 1978).
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McIntosh et al., Can. J. Chem., vol. 56 (1978) pp. 226-231.
Patai et al., J. Org. Chem., vol. 25 (1960) pp. 1232-1234.

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