Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-11-29
1997-08-12
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 8, 514 12, 514 21, 530324, 530395, 530400, 530833, 426532, 426657, 424439, A61K 3716, A23L 334
Patent
active
056565917
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/JP92/01563, filed Nov. 30, 1992.
TECHNICAL FIELD
The present invention relates to antimicrobial agents and method for treating products therewith. More particularly, the present invention relates to new antimicrobial agents having excellent antimicrobial activity against a wide, variety of microorganisms, and method for safely treating various products, e.g., foods, medicines, and the like with such an agent.
BACKGROUND ART
It is known that lactoferrin is a natural iron-binding protein occurring in vivo, e.g. in lacrima, saliva, peripheral blood, milk and the like, and that it exhibits antimicrobial activity against various harmful microorganisms belonging to the genera of Escherichia, Candida, Closridium, and the like (Journal of Pediatrics, Vol. 94, Page 1, 1979). It is also known that lactoferrin exhibits antimicrobial activity, in a concentration of 0.5-80 mg/ml, against microorganisms belonging to the genera of Staphylococcus and Enterococcus (Nonnecke, B. J. and Smith, K. L.: Journal of Dairy Science, Vol. 67, page 606, 1984).
On the other hand, a number of inventions are known for peptides having antimicrobial activity against various microorganisms. Some examples of such peptides are: phosphono-tripeptide (Japanese Unexamined Patent Application Gazette No. 57(1982)-106689), phosphono dipeptide derivatives (Japanese Unexamined Patent Application Gazette No. 58(1983)-18594), and cyclic peptide derivatives (Japanese Unexamined Patent Application Gazette No. 58(1983)-213744) which are effective against Gram positive and Gram negative bacteria; peptides having antimicrobial and antiviral activities (Japanese Unexamined Patent. Application Gazette No. 59(1984)-51247); polypeptides effective against yeast (Japanese Unexamined Patent Application Gazette No. 60(1985)-130599); glycopeptides derivatives effective against Gram positive bacteria (Japanese Unexamined Patent Application Gazette Nos. 60(1985)-172998, 61(1986)-251699, 63(1988)-44598); oligopeptides effective against Gram positive bacteria (Japanese Unexamined Patent Application Gazette No. 62(1987)-22798); peptide antibiotics (Japanese Unexamined Patent Application Gazette Nos. 62(1987)-51697, 63(1988)-17897); antimicrobial peptides extracted from blood cells of Tachypleus tridentalus from North America (Japanese Unexamined Patent Application Gazette No. Heisei 2(1990)-53799); antimicrobial peptides isolated from hemolymph of bees (Japanese Unexamined Patent Application (via PCT root) Gazette No. Heisei 2(1990)-500084), and the like.
The inventors of this invention contemplated to isolation of useful substances, which do not have undesirable side effects (e.g. antigenicity) and which have heat-resistance as well as potent antimicrobial activity, from nature at a reasonable cost, and found the fact that hydrolysates of lactoferrin obtainable by acid or enzyme hydrolysis of mammalian lactoferrin, apo-lactoferrin, and/or metal chelated lactoferrin (hereinafter they are referred to as lactoferrins) have more potent heat-resistance and antimicrobial activity than unhydrolyzed lactoferrins, for which a patent application has been filed (Japanese Patent Application No. Heisei 3(1991)-171736).
Furthermore, the inventors of this invention previously found a number of peptides, originated from the lactoferrins, which do not have side effects (e.g. antigenicity), and which have heat-resistance as well as a potent antimicrobial activity, e.g. antimicrobial peptides having 20 amino acid residues (Japanese Patent Application No. Heisei 3(1991)-186260), antimicrobial peptides having 11 amino acid residues (Japanese Patent Application No. Heisei 3(1991)-48196), antimicrobial peptides having 6 amino acid residues (Japanese Patent Application No. Heisei 3(1991)-94492), antimicrobial peptides having 5 amino acid residues (Japanese Patent Application No. Heisei 39(1991)-94493), and antimicrobial peptides having 3-6 amino acid residues (Japanese Patent Application No. Heisei 3(1991)-94494), for which patent applications have been
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Tomita et al, J. Dairy Sci, vol. 74, No. 12, pp. 4137-4142, 1991.
Kruzel, Chemical Abtract, vol. 116, p. 464, Ref. #19747j, 1991 (PCT Int. Appl. WO91,13982, 19 Sep. 1991).
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Bellamy Wayne Robert
Fukuwatari Yasuo
Kawase Kozo
Shimamura Seiichi
Takase Mitsunori
Mohamed Abdel A.
Morinaga Milk Industry Co. Ltd.
Tsang Cecilia J.
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