Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2008-01-29
2008-01-29
Padmanabhan, Sreeni (Department: 1617)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S301000, C564S080000, C564S084000, C564S090000, C564S092000, C564S093000
Reexamination Certificate
active
07323596
ABSTRACT:
Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(═O) or of formula C(═O)NH(OH); R1represents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(═O), a hydroxy or amino group; R2represents a radical of formula R10—(X)n-(ALK)m- wherein R10represents hydrogen, or an optionally substituted c1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C1-C6alkylene, C2-C6 ?alkenylene, or C2-C6alkynylene radical, and may be interrupted by one or more non-adjacent NH—, —O— or S— linkages, X represents NH—, —O— or S—, and m and n are independently 0 or 1; R3represents hydrogen, C1-C6alkyl, or benzyl; and R4is as defined in the specification.
REFERENCES:
patent: WO 9108737 (1991-06-01), None
patent: WO 00 35440 (2000-06-01), None
Scozzafava: “Protease inhibitors part 12” Eur. J. Pharm.Sci., vol. II, Jul. 2000, pp. 69-79, XP000971120 Table 2 Discussion about lead compound 4, p. 75, left-hand column, p. 71, left hand column, paragraph 1.
Scozzafava A et al: “Protease inhibitors—Part 5. Alkyl/arylsulfonyl—and arylsulfonylureido-/arylureido-glycine hydroxamate inhibtors ofClostridium histolyticumcollagenase” European Journal of Medicinal Chemistry, Editions Scientifieuqe Elsevier, Paris, FR, vol. 35, No. 3, Mar. 2000, pp. 299-307, XP004341234 ISSN 0223-5234 Table 1 last 7 lines, p. 300, left-hand column.
Broughton et al: “Studies concerning the Antibiotic Actinonin” Journal of the Chemical Society, Perkin Transactions 1, Chemical Society. Letchworth, GB, vol. 9, 1975, pp. 857-860, XP002157880, ISSN: 1472-7781, cited in the application example 21.
Beckett Raymond
Gane Paul
Keavey Kenneth
Porter Barry
Saroglou Lydia
Banner & Witcoff , Ltd.
Carter Kendra D.
De Novo Pharmaceuticals Ltd.
Padmanabhan Sreeni
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