Antimicrobial agents

Details Antimicrobial agents Antimicrobial agents

1976-09-03

1978-05-16

Demers, Arthur P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260552SC, 260554, 544380, C07C10319

Patent

active

040899004

ABSTRACT:
4-Dedimethylaminotetracyclines and the corresponding 5a,6-anhydro derivatives having an oxo, hydroxy, substituted imino, amino or substituted amino group other than dimethylamino at the C.multidot.4-position useful as antimicrobial agents. The 4-oxo-4-dedimethylaminotetracyclines are prepared by oxidation of tetracyclines with a hydrocarbon dicarboxylic acid haloimide and then converted by reduction to the corresponding 4-hydroxy compounds or by reaction with a primary amine to 4-substituted imino derivatives. The latter compounds are reduced to 4-amino derivatives which are reductively methylated or alkylated to 4-substituted-4-dedimethylaminotetracyclines. Dehydration of the tetracycline compounds affords the corresponding 5a,6-anhydro compounds.

REFERENCES:
patent: 3183267 (1965-05-01), Blackwood et al.
patent: 3200149 (1965-08-01), Blackwood et al.
Blackwood et al., J. Am. Chem. Soc., 83, (1961), pp. 2773-2775.

Affiliated with

Also associated with

Rating

Antimicrobial agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antimicrobial agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antimicrobial agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1197491