Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-06-13
2006-06-13
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200
Reexamination Certificate
active
07060677
ABSTRACT:
The present invention provides polypeptides related to human lactoferrin protein that have utility in a variety of therapeutic and prophylactic applications, including use as antimicrobial agents. The invention further provides pharmaceutical compositions containing these polypeptides and therapeutic methods using such compositions. Methods for detecting antimicrobial infections using the polypeptides are also provided.
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Ellison et al., “Image of the outer membrane of enteric gram-negaive bacteria by lactoferrin and transferring”, Infection and Immunity, vol. 56, No. 11, 1988, pp. 2774-2781.
Groenink et al., “Cationic amphipathic peptides, derived from bovine and human lactoferrins, with antimicrobial activity against oral pathogens”, FEMS Microbiology Letters, vol. 179, No. 2, Oct. 15, 1999, pp. 217-222.
Nibbering et al., “Human lactoferrin and peptides derived from its N-terminus are highly effective against infections with antibiotic-resistant bacteria”, Infection and Immunity, vol. 69, No. 3, Mar. 2001, pp. 1469-1476.
Nibbering Peter Hendikus
Nuijens Jan Henricus
Van Berkel Patrick H. C.
AM-Pharma B.V.
Campell Bruce R.
Teller Roy
Townsend and Townsend / and Crew LLP
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