Antimicrobial 8-substituted benzo [IJ]quinolizines

Details Antimicrobial 8-substituted benzo [IJ]quinolizines Antimicrobial 8-substituted benzo [IJ]quinolizines

1981-11-06

1983-09-13

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 94, A01N 4342, A61K 3147, C07D45504

Patent

active

044042078

ABSTRACT:
Antimicrobial compounds of the following formula are disclosed: ##STR1## wherein Het is selected from the goup consisting of pyrryl, pyrrolidyl, tetrazolyl of the formula ##STR2## wherein R.sup.1 is lower alkyl or benzyl and oxadiazolyl of the formula ##STR3## wherein R.sup.2 is lower alkyl, trifluoromethyl or --NH.phi.--; X is hydrogen and when Het is pyrryl or pyrrolidyl, X may be fluorine. Pharmaceutically acceptable carboxylate salts and esters of the acids are also disclosed.

REFERENCES:
patent: 3896131 (1975-07-01), Gerster
patent: 3985882 (1976-10-01), Gerster
patent: 4238487 (1980-12-01), Bicking
patent: 4251537 (1981-02-01), Evans
patent: 4281014 (1981-07-01), Yaffee

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