Antimicrobial 8,9-dihalobenzo[ij]quinolizine carboxylic acids

Details Antimicrobial 8,9-dihalobenzo[ij]quinolizine carboxylic acids Antimicrobial 8,9-dihalobenzo[ij]quinolizine carboxylic acids

1981-11-06

1985-06-18

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 94, 546165, 546166, 546171, 546180, A61K 3144

Patent

active

045241481

ABSTRACT:
The compounds 8-bromo-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quiniolizine-2- carboxylic acid and 8-chloro-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H,-benzo[ij]quinolizine-2 -carboxylic acid are disclosed as potent antimicrobials. Pharmaceutically-acceptable carboxylate salts, acyl chlorides, esters and alkylaminoalkyl ester salts of the acids are also disclosed.

REFERENCES:
patent: 3896131 (1975-07-01), Gerster
Chemical Abstracts, 46: 5588d (1952), [Sveinbjornsson, A., et al., J. Org. Chem., 16, 1450-1452, (1951)].
Chemical Abstracts, 94: 71503t (1981), [Japan. Kokai 80, 118, 416, 9/11/80].
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 313 and 554.

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