Antimicrobial 2-deoxystreptamine compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C536S013300, C536S016600, C536S016800

Reexamination Certificate

active

06967242

ABSTRACT:
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention comprises at least one aryl, heteroaryl, substituted aryl or substituted heteroaryl group in place of a glycosyl group attached to the 2-deoxystreptamine ring.

REFERENCES:
patent: 4247687 (1981-01-01), Hanessian
patent: 5942547 (1999-08-01), Gustafson et al.
patent: 6140361 (2000-10-01), Gustafson et al.
patent: 55015445 (1980-02-01), None
Greene, T. “Protective Groups in Organic Synthesis” John Wiley & Sons, 1981, pp 29-39.
Alper, P.B. et al., “Probing the Specificity of Aminoglycoside-Ribosomal RNA Interactions with Designed Synthetic Analogs,”J. Am. Chem. Soc., 1998, 120, 1965-1978.
Ding, Y et al., “Efficient synthesis of neomycin B related aminoglycosides”,Tet Lett., 2000, 41, 4049-4052.
Greenberg, W.A. et al., “Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: correlation of antibiotic activity with in vitro inhibition of translation”,J. Am. Chem. Soc., 1999, 121, 6527-6541.
Kumar, V., et al., “Aminoglycoside antibiotics,”J. Org. Chem., 1981, 46, 4298-4230.
Moazed, D. et al., “Interaction of antibiotics with functional sites in 16S ribosomal RNA,”Nature, 1987, 327, 389-394.
Tamura, J., et al., “The synthesis of destomycin C,” 1988, 174, 181-199.
van Stratten, N., et al., “An expeditious route to the synthesis of adenophostin A,”Tetrahedron, 1997, 53(18), 6509-6522.

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