Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic a

Details Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic a Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic a

1985-08-16

1988-07-05

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544363, A61K 31495, C07D40104

Patent

active

047555130

ABSTRACT:
Novel 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or an alkyl having 1 to 2 carbon atoms, R.sup.2 is hydrogen atom or fluorine atom, and R.sup.3 is hydroxy, fluorine atom or an alkanoyloxy having 1 to 6 carbon atoms, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.

REFERENCES:
patent: 4398029 (1983-08-01), Irikura et al.
patent: 4429127 (1984-01-01), Irikura et al.
patent: 4448962 (1984-05-01), Irikura et al.
patent: 4528287 (1985-07-01), Itoh et al.
Chu, "Chemical Abstracts", vol. 103, 1985, col. 103:123373b.

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