Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-02-14
1995-04-25
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546150, A61K 3147, C07D21702, C07D21704, C07D21706
Patent
active
054099382
ABSTRACT:
The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial korupensamines from the plant Ancistrocladus korupensis, methods for obtaining new korupensamine derivatives, antimalarial compositions containing such antimalarial korupensamines or derivatives thereof or pharmacologically acceptable salts thereof, and methods of using such antimalarial compounds for the prevention of malaria infections or for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.
REFERENCES:
patent: 5025020 (1991-06-01), Van Dyke
patent: 5260315 (1993-11-01), Bringmann et al.
Bringmann et al., "The absolute configuration of michellamine B, a `dimeric`, anti-HIV-active naphthylisoquinoline alkaloid," Angew. Chem. (International Edition-English), 32, 1190-1191 (1993).
Bringmann et al., "The determination of the absolute configuration of N-methylated 1,3-dimethyltetrahydroisoquinolines by oxidative degradation," Planta Med., 59 (supp.), A619-A620 (1993).
Bringmann et al., "Feeding deterrency and growth retarding activity of the naphthylisoquinoline alkaloid dioncophylline A against spodoptera littoralis," Phytochemistry, 31, 3821-3825 (1992).
Bringmann et al., "Ancistrobrevine B, the first naphthylisoquinoline alkaloid with a 5,8'-coupling site, and related compounds from ancistrocladus abbreviatus,"Phytochemistry, 31, 4011-4014 (1992).
Bringmann et al., "Ancistobrevine D: An unusual alkaloid from ancistrocladus abbreviatus," Planta Med., 58 (Supp. 1), A703-A704 (1992).
Bringmann et al., "A facile degradation procedure for determination of absolute configuration in 1,3-dimethyltetra- and dihydroisoquinolines," Phytochemistry, 30, 2067-2070 (1991).
Bringmann et al., "On the structure of these dioncophyllaceae alkaloids dioncophylline A (triphyophylline) and O-methyltriphyophylline," Tetrahedron Lett., 31, 639-642 (1990).
Bringmann et al, "On the biosynthesis of acetogenic tetrahydrodroisoquinoline alkaloids: first in vivo feeding experiments," Planta Med., 57 (supp. 2), A98 (1991).
Bringmann, "The Naphthyl Isoquinoline Alkaloids,"0 in The Alkaloids, vol. 29, (Brossi, ed.), Chapter 3, 141-184 (Academic Press, New York, 1986).
Chen et al., "Isolation and identification of the alkaloids from ancistrocladus tectorius," Yao Hsueh Hsueh Pao (China) (i.e., Acta Pharmaceutica Sinica), 16, 519-523 (1981).
Desjardins et al., "Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique," Antimicrobial Agents Chemother., 16, 710-718 (1979).
Foucher et al., Plantes Med. Phytother., 9, 87-98 (1975).
Grimm et al., "Deleterious effects of naphtylisoquinoline alkaloids on survival and growth of spodoptera littoralis," Planta Med., 58 (Sup. 1), 630 (1992).
Guinaudeau et al., "Bisbenzylisoquinoline alkaloids from cyclea barbata," J. Nat. Prod., 56 1989-1992 (1993).
Likhitwitayawuid et al., "Cyctotoxic and antimalarial bisbenzylisoquinoline alkaloids from stephania erecta," J. Nat. Prod., 56, 30-38 (1993).
Lin et al., "Cyctotoxic and antimalarial bisbenzylisoquinoline alkaloids from cyclea barbata," J. Nat. Prod., 56, 22-29 (1993).
Manfredi et al., "Novel alkaloids from the tropical plant ancistrocladus abbreviatus inhibit cell killing by HIV-1 and HIV-2," J. Med. Chem., 34, 3402-3405 (1992).
Pavanand et al., "Antimalarial activity of tiliacora triandra dields against plasmodium falciparum in vitro," Phytother. Res., 3, 215-217 (1989).
Ruangrungsi et al., "Traditional medicinal plants of Thailand, V. ancistrotectorine, a new naphthaleneisoquinoline alkaloid from ancistrocladus tectorius," J. Nat. Prod., 48, 529-535 (1985).
Sharma et al., "Alkaloids and terpenoids of ancistorcladus heyneanus, sagittaria sagitifolia, lyonia formosa and hedychium spicatum," Phytochemistry, 14, 578-579 (1975).
Thomas et al., "Ancistrocladus korupensis (ancistroclasaceae): A new species of liana from Cameroon," Novon, 3 (4), 494-498 (1993).
Trager et al., "Human malarial parasites in continuous culture," Science, 193, 673-675 (1976).
Ye et al., "Selective antimalarial activity of tetrandine against chloroquinone resistant plasmodium falciparum," Biochem. Biophys. Res. Com., 159, 242-248 (1989).
Boyd Michael R.
Bringmann Gerhard
Cardellina, II John H.
Francois Guido
Hallock Yaii F.
Dentz Bernard
The United States of America as represented by the Secretary, De
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