Antimalarial drugs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514299, A61K 3136, A61K 3144

Patent

active

058345051

ABSTRACT:
An antimalarial drug combination for prophylactic treatment or curative treatment of malaria comprises a first component which is a fenozan, that is a cis-fused cyclopenteno-1,2,4-trioxane, and a second component which is another antimalarial drug.

REFERENCES:
Microbiological Reviews, Jun. 1996, "Artemisinin and the Antimalarial Endoperoxides: from Herbal Remedy to Targeted Chemotherapy", vol. 60, No. 2, pp. 301-315.
W. Peters, et al., Annals of Tropical Medicine and Parasitology, 1970, vol. 64, pp. 41-51.
W. Peters, et al., Annals of Tropical Medicine and Parasitology, vol. 87, pp. 9-16 (1993).
Charles W. Jefford, J. Chem. Soc., Chem. Commun., 1984, pp. 523-524.
W. Clark Still, et al., J. Am. Chem. Soc., 1983, vol. 105, pp. 625-627.
Charles W. Jefford, J. Am. Chem. Soc., 1983, vol. 105 pp. 6497-6498.
Jefford, et al., Chemical Abstract, 1987, vol. 106, No. 15, pp. 645, col. 1, abstract no. 119857g.
Helvetica Chimica Acta, vol. 69, 1986, pp. 941-948.

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