Antimalarial analogs of artemisinin

Details Antimalarial analogs of artemisinin Antimalarial analogs of artemisinin

1990-03-23

1993-06-01

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49118

Patent

active

052161757

ABSTRACT:
Polyoxoheterocyclic tetracycles related to the Chinese antimalarial natural product qinghaosu (artemisinin) are disclosed. These materials have a ##STR1## core structure with an oxygen (carbonyl or alkyl ether) at position 12 and in some cases one or two alkyl or aralkyl substituents at position 11. These materials have antimalarial properties.

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