Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-11-19
2000-06-06
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, G01N 3353, C07K 500, C07K 1400
Patent
active
060717106
ABSTRACT:
An analog of the peptide consisting of RPPGF (SEQ ID N0:1) is provided. Mimetics of RPPGF (SEQ ID NO:1) and its retropeptide, FGPPR, are also provided. A peptide is provided having an antikinin activity and having the sequence X.sub.1 -R-P-P-G-F-X.sub.2 (SEQ ID NO:5), X.sub.1 -F-G-P-P-R-X.sub.2 (SEQ ID NO:7). Provided are methods of screening for a mimetic or analog of RPPGF (SEQ ID NO:1) or FGPPR (SEQ ID NO:2), screening for an RPPGF (SEQ ID NO:1) receptor, or screening for an antagonist of RPPGF (SEQ ID NO:1) or FGPPR (SEQ ID NO:2) is provided. Methods of treating conditions that can be treated by an antikinin activity and diseases that are associated with an antikinin activy are also provided.
REFERENCES:
patent: 5385899 (1995-01-01), Kyle et al.
patent: 5834431 (1998-10-01), Stewart et al.
Liebmann, C. et al., Descrimination Between Putative Bradykinin B2 Receptor and Subtypes in Guinea Pig Ileum Smooth Iodinable Bradykinin Analog, Molecular Pharmacology, 46:949-956, 1994.
De Vries J.G., et al., Construction of a Physiologically Active Photaffinity Probe Based on the Structure of Bradykinin, Journal of Neurochemistry 52:5:1508-1516, 1989.
Suzuki, Jenji & Abiko, Takashi, Syntheis of Every Kind of Peptide Fragments of Bradykinin, Chem. Pharm. Bull. 17:8:1671-1678, 1969.
Stahl, K.W., Purification and Gel Filtration Chromatography (GFC) of an Antiinflammatory and Macrophogotoxic Peptide from Murine Malignant Cells, Proc. Eures Symp. Macrophage Cancer 271-280, 1977.
Miller, L.J., et al., Preparation and Characterization of a Probe for the Cholecystokinin Octrapeptide Receptor, N.sup..alpha. (.sup.125 I-desaminotyrosyl) CCK-8, and its Interactions with Pancreatic Acini, J. Biol. Chemistry, 256:23:12417-12423, 1981.
Hasan, A.A.K., Amenta, S. and Schmaier, A.H., "Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe are selective inhibitors of .alpha.-thrombin-induced platelet activation", Circulation 94:517-528, 1996.
Majima, M., Sunahara, N., Harada, Y., and Katori, M.: "Detection of the degradation products of bradykinin by enzyme immunoassays as markers for the release of kinin in vivo" Biochem. Pharmacol. 45:559-567, 1993.
Shima, C., Majima, M., and Katori, M., "A stable metabolite, Arg-Pro-Pro-Gly-Phe, of bradykinin in the degradation pathway in human plasma", Japan J. Pharmacol. 60:111-119, 1992.
08/,675,821 01/1999 Rosazza et al. 435 191.
Basi Nirmal S.
Kemmerer Elizabeth
MUSC Foundation for Research Development
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