Antiinflammatory pyrazole thioureas

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424263, 424266, 424273P, 546153, 546159, 546162, 546163, 546256, 546279, 548362, A61K 3147, C07D40104

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active

044656858

ABSTRACT:
Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents.
The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation.
The compounds may be prepared by methods analogous to those known in the art, e.g. by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.

REFERENCES:
patent: 3646059 (1972-02-01), Brantley
Duffin et al., J. Chem. Soc., 1954, pp. 408-415.

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