Antiinflammatory peptide derived from human lipocortin V

Details Antiinflammatory peptide derived from human lipocortin V Antiinflammatory peptide derived from human lipocortin V

1991-01-18

1993-07-20

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530300, 530328, A61K 3764, A61K 3702, C07K 706

Patent

active

052293670

ABSTRACT:
The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val-Phe-Asp-Lys-OH (SEQ ID NO. 1) and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. The peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.

REFERENCES:
patent: 4895931 (1990-01-01), Okazaki et al.
patent: 5081019 (1992-01-01), Wallner et al.
Devereaux et al., 12 Nucleic Acid Res. 387-395 (1984).
Cirino et al., 86 Proc. Natl. Acad. Sci. USA 3428-3432 (1989).
Cirino et al., 166 Eur. J. Pharmacol. 505-510 (1989).
K. S. Huang et al., Journal of Biological Chemistry 262:7639-7645, Jun. 5, 1987.
B. P. Wallner et al., Nature 320:77-81, Mar. 6, 1986.
L. Miele et al., Nature 335:726-730, Oct. 20, 1988.

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