Antiinflammatory imidazothiazoles and thiazolopyrimidines

Details Antiinflammatory imidazothiazoles and thiazolopyrimidines Antiinflammatory imidazothiazoles and thiazolopyrimidines

1979-04-02

1980-09-23

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548324, A61K 31425, C07D27700

Patent

active

042243343

ABSTRACT:
Certain imidazothiazoles and thiazolopyrimidines have been found to prevent and inhibit the formation of granuloma tissue in animals. This result is accomplished by administering to the animal subject a therapeutically effective amount of a compound having the formula: ##STR1## wherein R is hydrogen or methyl, R' is hydrogen, lower alkyl or thioalkyl, carboxy methyl, or phenyl; R" is lower alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl. The hydrated precursors of certain of these compounds as well as the acid addition and quaternary salts of both the compounds and their hydrated precursors may be employed.

REFERENCES:
patent: 3673206 (1972-06-01), Bullock et al.
patent: 4008245 (1977-02-01), Acheson et al.
patent: 4042583 (1977-08-01), Acheson et al.
Chem. Abst., 74-13059d (1971).
Inpharma, 20th Mar. 1976, p. 19 (AD is Press).
Chem. Abst., 75-63677v (1971).
Merck Index, 9th ed. p. 8949.
Chem. Abst., 76-1131625 (1972).
Chem. Abst., 72-79041g (1970).
Chem. Abst., 76-419194 (1972).
Pharmazie, 20, 629-633 (1965).

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