Antiinflammatory compositions and method of use

Details Antiinflammatory compositions and method of use Antiinflammatory compositions and method of use

1991-01-22

1993-03-23

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514316, 514321, 5142325, 5142338, A61K 31335, A61K 31445, A61K 31535

Patent

active

051964481

ABSTRACT:
Esters of silybin with dicarboxylic acids, and the salts thereof, are antiinflammatory agents. A typical example is the disodium salt of the bis-(hemisuccinate).

REFERENCES:
patent: 4895839 (1990-01-01), Bombardelli
Merck Index, 10th Ed. (1983), Monograph No. 8372.
Ely, "Dermatologic Therapies You've Probably Never Heard Of", Dermatologic Clinics, vol. 7 (1989) pp. 19, 25-28.
Bonne et al., "Screening Tests of Free Ridical Scavengers for Preventing Sun-Accelerated Cutaneous Ageing", Intl. J. Cosmetic Sci., vol. 10 (1988) pp. 247-252.
Weber, et al., "The Liver-A Therapeutic Target in Cases of Dermatosis", Medwelt, vol. 34 (1983) pp. 50-55.
"Chemistry of Silymarin and Water-Soluble Derivatives", Symposium on the Pharmacodynamics of Silymarin (1976) pp. 7-12.
Stedman's Medical Dictionary, 24 Ed., Williams & Wilkins, Baltimore, Md., p. 1509.

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