Antiinflammatory cell adhesion inhibitors

Details Antiinflammatory cell adhesion inhibitors Antiinflammatory cell adhesion inhibitors

1997-10-10

2000-08-29

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514 61, 514 62, 536 172, 536 185, 536 55, 536 551, 536 552, 536 553, A61K 3170, C07H 1500

Patent

active

061108979

ABSTRACT:
The invention relates to compounds of formula Ix and Ia: ##STR1## wherein (Ix) comprises the regioisomeric form sLe.sup.X and (Ia) comprises the regioisomeric form sLe.sup.A, and R.sup.1 is a lipophilic radical formed from aliphatic or cycloaliphatic units, or a sugar residue which is capped by a .beta.1-O-linked aliphatic or cycloaliphatic unit at the reducing end of the terminal sugar. The compounds of the present invention are useful as inhibitors of increased cell-cell adhesion as well as useful in treating diseases associated with increased cell-cell-adhesion. The compounds of the present invention are also incorporated into pharmaceutical compositions.

REFERENCES:
Giannis Angew. Chem. Int. Ed. Engl. 1994, 33(2), 178-180, month not available.
A. Giannis, "Die Sialyl-Lewis-X-Gruppe und ihre Analoga als Liganden fur Selektine", Angew. Chem.. vol. 106:188-191, (1994), months not available.
Nelson et al., "Higher-Affinity Oligosaccharide Ligands For E-Selectin", J. Clin. Invest., vol. 91:1157-1166, (1993), months not available.
Cavallo et al. Carbohydrate Research Oct. 1993, 248, 251-265.
Heavner Drug Discovery Today Jul. 1996, 1(7), 295-304.

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