Antiinflammatory azole derivatives

Details Antiinflammatory azole derivatives Antiinflammatory azole derivatives

1975-10-21

1977-09-27

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424270, A61K 3142, A61K 31425

Patent

active

040512509

ABSTRACT:
Azole derivatives of the formula ##STR1## wherein R.sub.1 is free or esterified carboxyl or other functionally modified carboxyl group, R.sub.2 and R.sub.3 each are aryl; A is C.sub.n H.sub.2n in which n is an integer from 1 to 10, inclusive; and Z is O or S; and the physiologically acceptable salts thereof, possess, with good compatibility, excellent antiphlogistic activity and, in particular, influence favorably the chronic progressive diseases of the joints, e.g., arthritis. They can be prepared from compounds of the formula ##STR2## wherein X.sub.1 is a group convertible into the group --S--A--R.sub.1, and R.sub.2 and R.sub.3 have the values given above.

REFERENCES:
patent: 2513923 (1950-07-01), Duffin et al.
patent: 3578671 (1971-05-01), Brown
patent: 3933840 (1976-01-01), Dahm et al.

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