Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes

Details Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes

1982-03-04

1984-02-21

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

546 14, 549 4, A61K 3138, A61K 3144, C07F 708, C07F 718

Patent

active

044329741

ABSTRACT:
2,3-Diaryl-5-silyl thiophenes, such as 2,3-bis(4-methoxyphenyl)-5-(trimethylsilyl)thiophene; 2,3-bis(4-methoxyphenyl)-5-(ethenyldimethylsilyl)thiophene; and 2,3-bis(4-methoxyphenyl)-5-[(2-propenyl)dimethylsilyl]-thiophene, are useful in the treatment of inflammation and/or pain.

REFERENCES:
patent: 2640833 (1953-06-01), DiGiorgio
patent: 2645644 (1953-07-01), DiGiorgio
Eaborn et al., J. Chem. Soc., (1961) pp. 4921-4927.
S. Hauptmann et al., J. Prakt. Chem. 314, 499-506 (1972).
J. L. Melles et al., Rec. Trav. Chim., 72, 314-328 (1953).
D. Habich et al., Synthesis, 841-876 (1979).
T. Kauffmann et al., Tet. Lett., 4039-4042 (1973).
F. H. Pinkerton et al., J. Het. Chem., 9, 725-728 (1972).
Slocum et al., J. Org. Chem., 41, 3668 (1976).
Knight et al., Tet. Lett., 21, 5051 (1980).

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