Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10

Details Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10 Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10

1993-10-21

1996-07-16

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, A61K 31505, C07D47104, C07D33338, C07D21381

Patent

active

055367240

ABSTRACT:
Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins and their 5 and 10 alkyl analogs. A method for the treatment and prevention of inflammatory disease, such as rheumatoid arthritis, and for suppression and prevention of neoplastic growth in tumors and in blood forming tissues. A process for preparation of 10-deazaaminopterins.

REFERENCES:
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patent: 5077404 (1991-11-01), Piper
patent: 5260296 (1993-11-01), Nair et al.
Piper, Chem Abs 109, 170844 (1988).
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Piper, J. R., et al., Studies Aided by Molecular Graphics of Effects of Structural Modifications on the Binding of Antifolate Inhibition to Human Dihydrofolate Reductase, Preclinical Pharmacology/Experimental Therapeutics Section, Proceedings of the American Association for Cancer Research, vol. 33, 2459-412 (Mar. 1992) Abstract 2459.

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