Antiinflammatory and analgesic transdermal gel

Details Antiinflammatory and analgesic transdermal gel Antiinflammatory and analgesic transdermal gel

1994-03-09

1996-06-18

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Solid synthetic organic polymer

514944, 424443, A61K 4732

Patent

active

055278329

ABSTRACT:
Transdermal gels comprising (1) ketoprofen as an effective component, (2) poloxamer, (3) one or more agents selected from ethyl alcohol, isopropyl alcohol, propylene glycol, polyethylene glycol and glycerin, (4) one or more agents selected from the group consisting of lauric acid, oleic acid, capric acid, myristic acid, lauryl alcohol, oleyl alcohol and menthol, (5) water or a buffer solution. The gels form thin and pliable films, which are easily washable with water. They possess prolonged antiinflammatory and analgesic activities and physicochemical stability with less systemic side effects and gastric irritation.

REFERENCES:
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patent: 4534980 (1985-08-01), Itoh et al.
patent: 4849418 (1989-07-01), Lohner
patent: 4956184 (1990-09-01), Kross
patent: 5256396 (1993-10-01), Piechota, Jr.
Yano et al., "Skin Permeability of Various . . .", Life Sciences, vol. 39, pp. 1043-1050, 1986.

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