Antiinflammatory and analgesic gel preparation

Details Antiinflammatory and analgesic gel preparation Antiinflammatory and analgesic gel preparation

1993-08-20

1995-06-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Anti-inflammatory or anti-irritant

424445, 514887, 514944, 514947, A61K 3174, A61L 1544

Patent

active

054221021

ABSTRACT:
An antiinflammatory and analgesic gel preparation comprising diclofenac or its salts, an ester of dibasic acid, a lower alcohol, and a nonionic polymer or a mixture of nonionic polymers selected from the group consisting of (a) 1.5-4% by weight of hydroxypropyl cellulose having a molecular weight of 500,000 or greater, (b) 2-4% by weight of hydroxyethyl cellulose having a molecular weight of 1,250,000 or greater, and (c) 1.5-4% by weight of a mixture of hydroxypropyl cellulose having a molecular weight of 500,000 or greater and hydroxyethyl cellulose having a molecular weight of 1,250,000 or greater, and having a viscosity of 5,000-35,000 cps and an yield value of 5 dyn/cm.sup.2 or greater. The gel preparation is excellent in the percutaneous absorption of diclofenac or its salts and provides good properties upon use and superior medical effects of diclofenac or its salts.

REFERENCES:
patent: 4789667 (1988-12-01), Makino et al.

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