Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-10-14
1988-06-14
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540556, A61K 3155, C07D48706
Patent
active
047512237
ABSTRACT:
There are disclosed compounds of the formula ##STR1## where X and Y are independently hydrogen, loweralkyl, trifluoromethyl or halogen; Z is --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 CH.sub.2 --; n is 1, 2 or 3; R.sub.1 is hydrogen, loweralkanoyl, aroyl, ethoxycarbonyl, phenoxycarbonyl, loweralkylaminocarbonyl, arylaminocarbonyl, loweralkyl or arylmethyl; R.sub.2 is hydrogen or loweralkyl; R.sub.3 is hydrogen, loweralkyl, ethoxycarbonyl, loweralkanoyl or arylloweralkyl, or R.sub.2 and R.sub.3 taken together is isopropylidene; with the proviso that when n is 3, X, Y and R.sub.1 are all hydrogen and Z is --CH.sub.2 CH.sub.2 --, R.sub.2 and R.sub.3 can not both be methyl. These compounds display antiinflammatory and analgesic activities.
REFERENCES:
patent: 4186199 (1980-01-01), Glamkowski et al.
patent: 4192874 (1980-03-01), Glamkowski et al.
patent: 4405631 (1983-09-01), Kosley, Jr. et al.
patent: 4438120 (1984-03-01), Rajagopalan
patent: 4447361 (1984-05-01), Taylor, Jr.
patent: 4521537 (1985-01-01), Kosley, Jr. et al.
Blickenstaff, et al., Chem. Abstracts, vol. 82 (1975), entry 4219u.
Glamkowski, et al., J. Heterocyclic Chem., 16, 865 (1979).
Glamkowski, et al., J. Med. Chem., 23, 1380 (1980).
Chiang Yulin
Ehrgott, Jr. Frederick J.
Glamkowski Edward J.
Daus Donald G.
Hoechst-Roussel Pharmaceuticals Inc.
Ikeda Tatsuya
Teoli, Jr. William A.
LandOfFree
Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiaze does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiaze, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiaze will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-505242