Antiinflammatory analgesic gelled ointment

Details Antiinflammatory analgesic gelled ointment Antiinflammatory analgesic gelled ointment

1983-02-22

1985-06-25

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Lymphokine

424 78, 514420, A61K 3140, A61K 3178

Patent

active

045253471

ABSTRACT:
An antiinflammatory analgesic ointment comprising: (a) an antiinflammatory amount of indomethacin; (b) a medium consisting of a hydroxy compound in the range of from 15 to 85% by weight, water in the range of 30 to 55% by weight and a gelating agent being present in an amount sufficient to effect gelation of said ointment and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia or an amine; (c) an adjuvant being present in the range of from 0.5 to 5% by weight and selected from the group consisting of a C.sub.1 -C.sub.5 alcohol ester of a C.sub.4 -C.sub.14 monocarboxylic acid and a C.sub.1 -C.sub.3 alcohol diester of a C.sub.4 -C.sub.10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of the ointment, said ointment being adjusted in its pH from an acidic to slightly basic level sufficient to solubilize said indomethacin in the composition but not too basic a pH level to cause decomposition of said indomethacin.

REFERENCES:
patent: 3629412 (1971-12-01), Silber et al.
patent: 4126681 (1978-11-01), Reller
patent: 4244942 (1981-01-01), Kamishita et al.

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