Antiinflammatory 2-(trifluoroethylsulfonyl)benzimidazoles

Details Antiinflammatory 2-(trifluoroethylsulfonyl)benzimidazoles Antiinflammatory 2-(trifluoroethylsulfonyl)benzimidazoles

1985-05-30

1986-08-26

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548329, A61K 31415, C07D23528

Patent

active

046083812

ABSTRACT:
Disclosed are novel 2-(2,2,2-trifluoroethylsulfonyl)-1H-benzimidazoles represented by formula I ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, halogen or C.sub.1 -C.sub.2 lower alkyl and nontoxic, pharmaceutically acceptable salts thereof as well as the corresponding trifluoroethylmercapto compounds which are useful as intermediates in making the compounds of Formula I. The compounds of Formula I can be used for the treatment of chronic inflammation and inflammatory diseases such as rheumatoid arthritis.

REFERENCES:
patent: 3705174 (1972-12-01), Fisher et al.
patent: 4190666 (1980-02-01), Cherkofsky et al.
patent: 4401817 (1983-08-01), Paget et al.

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