Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1974-09-09
1976-10-05
Gotts, Lewis
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
2602472A, 2602475FP, 260326N, 26032611R, 26032614R, 26032614A, 26032615, 260488CD, 260518R, 260562H, 424248, 424309, 424317, 424324, C07D20914, A61K 3140
Patent
active
039845630
ABSTRACT:
Compounds with antiinflammatory, analgesic and CNS depressant activity having the following general formula ##SPC1##
Wherein
R represents hydrogen or methoxy;
R.sub.1 represents hydrogen; lower alkyl; lower alkyl substituted with a group carboxy, carbo(lower alkoxy) or carbamyl; phenyl; benzyl, lower aliphatic acyl; benzoyl; benzoyl substituted with a halo group;
R.sub.2 represents hydrogen; lower alkyl; carbo(lower alkoxy); carbamyl; phenylcarbamyl; lower aliphatic acyl; benzoyl; benzoyl substituted with a halo group,
R.sub.3 represents halo; lower alkyl; lower alkyl substituted with a group selected from carboxy, carbo(lower alkoxy), carbamyl, halo, amino, mono and di-lower alkylamino, phthalimido and morpholino; phenyl; phenyl substituted with a group selected from lower alkoxy, halo, nitro, amino and acetamido;
R.sub.4 represents hydrogen or lower alkyl; with the proviso that when simultaneously R.sub.1 represents hydrogen, methyl, phenyl, benzyl, acetyl or benzoyl, R.sub.2 represents hydrogen, lower alkyl or acetyl,
R.sub.3 represents lower alkyl or phenyl, R.sub.4 must be different from hydrogen and methyl;
Or R.sub.3 and R.sub.4 taken together with the adjacent carbon atom may represent a 5-6 membered alicyclic ring.
REFERENCES:
patent: 3320278 (1967-05-01), Ruyle et al.
patent: 3869471 (1975-03-01), Richter et al.
Kebrle et al., Chem. Abstracts, vol. 50, pp. 6426i-6427i (1956).
Kost et al., Chem. Abstracts, vol. 76, pp. 301-302, No. 34047e and Chem. Subst. Index, 2H-Indol-2-imine (1972).
Golubeva et al., Chem. Abstracts, vol. 79, p. 433, No. 31782s and Chem. Subst. Index, 2H-Indol-2-imine (1973).
Di Mola Nunzio
Winters Giorgio
Bjork C. Kenneth
Gotts Lewis
Gruppo Lepetit S.p.A.
Post Theodore
Williams S. P.
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