Antiinflammatory 1-(quinolinyl)-2-pyrazoline derivatives

Details Antiinflammatory 1-(quinolinyl)-2-pyrazoline derivatives Antiinflammatory 1-(quinolinyl)-2-pyrazoline derivatives

1981-08-17

1983-10-04

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546153, 546155, 546157, 546159, 546167, 546171, A61K 3147, C07D40104

Patent

active

044078030

ABSTRACT:
Described are compounds of the formula ##STR1## wherein R.sub.2 -R.sub.8 independently of one another denote hydrogen, loweralkyl, phenyl, alkoxy, halo, hydroxy, nitro, trifluoromethyl, ##STR2## with the proviso that at least one but no more than one of the substituents R.sub.2 -R.sub.8 is ##STR3## and with the further provisos that at least four of the substituents R.sub.2 -R.sub.8 are hydrogen and R.sub.2 cannot be ##STR4## when R.sub.3 -R.sub.8 are hydrogen, and pharmaceutically acceptable salts thereof.
The compounds are effective as antiinflammatory and antiasthma agents.

REFERENCES:
patent: 3169966 (1965-02-01), Schmidt et al.
patent: 3996231 (1976-12-01), Wermouth et al.
patent: 4226773 (1980-10-01), Kynel
Finar, et al., Chemical Abstracts, vol. 53, 7173d (1959).

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