Antiinfective compounds and methods of use

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 7817, A61K 3174, A61K 31765

Patent

active

058110887

ABSTRACT:
In accordance with the present invention, a composition and method is provided that is effective in treating infections caused by microorganisms including, but not limited to, bacteria, viruses, and fungi. The present invention is effective in inhibiting the growth of bacteria such as Mycobacterium species including, but not limited to, Mycobacterium avium-intracellulare complex and M. tuberculosis. The present invention comprises a surface active copolymer, preferably an ethylene oxide-propylene oxide condensation product with the following general formula:

REFERENCES:
patent: Re29909 (1979-02-01), Kurtz
patent: 2674619 (1954-04-01), Lundsted
patent: 2854378 (1958-09-01), Buckwalter
patent: 2979528 (1961-04-01), Lundsted
patent: 3022335 (1962-02-01), Lundsted
patent: 3036118 (1962-05-01), Jackson et al.
patent: 3089818 (1963-05-01), Stone
patent: 3140232 (1964-07-01), Noseworthy
patent: 3228834 (1966-01-01), Gans et al.
patent: 3450502 (1969-06-01), Hymes
patent: 3577522 (1971-05-01), Hymes
patent: 3590125 (1971-06-01), Hymes
patent: 3641240 (1972-02-01), Hymes et al.
patent: 3740421 (1973-06-01), Schmolka
patent: 3867521 (1975-02-01), Miskel et al.
patent: 3867533 (1975-02-01), Schmolka
patent: 4100271 (1978-07-01), Krezanoski
patent: 4323560 (1982-04-01), Baschang et al.
patent: 4395393 (1983-07-01), Schmolka
patent: 4407790 (1983-10-01), Oakes et al.
patent: 4409209 (1983-10-01), Baschang et al.
patent: 4410660 (1983-10-01), Straus
patent: 4423038 (1983-12-01), Baschang et al.
patent: 4489158 (1984-12-01), Straus
patent: 4575484 (1986-03-01), Straus
patent: 4606918 (1986-08-01), Allison et al.
patent: 4609546 (1986-09-01), Hiratani
patent: 4801452 (1989-01-01), Hunter et al.
patent: 4837014 (1989-06-01), Hunter et al.
patent: 4837083 (1989-06-01), Hunter et al.
patent: 4879109 (1989-11-01), Hunter
patent: 4897263 (1990-01-01), Hunter
patent: 4937070 (1990-06-01), Hunter
patent: 4997644 (1991-03-01), Hunter
patent: 5017370 (1991-05-01), Hunter et al.
patent: 5028599 (1991-07-01), Hunter
patent: 5030448 (1991-07-01), Hunter
patent: 5032394 (1991-07-01), Hunter
patent: 5039520 (1991-08-01), Hunter
patent: 5041288 (1991-08-01), Hunter
patent: 5047236 (1991-09-01), Hunter et al.
patent: 5064643 (1991-11-01), Hunter et al.
patent: 5071649 (1991-12-01), Hunter
patent: 5078995 (1992-01-01), Hunter et al.
patent: 5080894 (1992-01-01), Hunter et al.
patent: 5089260 (1992-02-01), Hunter et al.
patent: 5250294 (1993-10-01), Hunter et al.
Cornforth et al., "Antituberculosis Effect of Certain Surface-Active Polyoxyethylene Ethers in Mice," Nature, vol. 168, pp. 150-153 (1951).
Lin, T. S. and Prusoff, W. H., "Synthesis and Biological Activity of Several Amio Analogs of Thymidine," J. Med. Chem., vol. 21, pp. 109-112 (1978).
McDougal, J. S., et al., "Immunoassay for the detection and Quantitation of infectious human retrovirus, lymphadenopathy-associated virus (LAV)," J. Immun. Meth. vol. 76, pp. 171-183 (1985).
Groopman, J. E., et al., "Characterization of serum neutralization response to the human immunodeficiency virus (HIV)," AIDS Res. Human Retro., vol. 3, pp. 71-85 (1987).
Spira, et al. "Micromethod for assaying the reverse transcriptase of LAV-HTLV-III/lymphadenopathy-associated virus." J. Clin. Microbiol., vol. 25, pp. 97-99 (1987).
Schinazi, R.F. et al., "Combinations of Isoprinosine and 3'-Azido-3'-Deoxythymidine in Lymphocytes Infected with Human Immunodeficiency Virus Type 1," Antimicrob. Agents Chemother. vol. 32, pp. 1784-1789 (1988).
Schinazi, R.F. et al., "Effect of combination of acyclovir, and vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice," Antimicrob. Agents Chemother., vol. 22, pp. 499-507 (1982).
Chou, T. C., and Talalay, P. "Quantitatuve analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors," Adv. Enz. Regul., vol. 22, pp. 27-55 (1984).
Weintraub, Harold M., "Antisense RNA and DNA," Scientific American, pp. 40-46 (Jan. 1990).
Atkinson, T.P. et al., "Ion transport mediated by copolymers composed of polyoxyethylene and polyoxypropylene," pp. C20-C26 (1988).
Benner, K.U. et al., "Uber die Wirkung von Pluronic.RTM. F68, einem Poloxypropylen-Polyoxyyyathylen-Kondensat, auf die ADP-induzierte Thrombocytenaggregation in vitro (The Effect of Pluronic.RTM. F68, a Polyoxypropylenepolyoxyethylene Condensate, on ADP-induced Platelet Aggregation in Vitro)," Pfugers Arch., vol. 315, pp. 45-52 (1970).
Benner, K.U., et al., "Cold-Induced Platelet Aggregation In Vivo And Its Inhibition By A Nonionic Surface Active Substance," Thrombosis Research, vol. 2, pp. 331-342 (1973).
Block, N.L. et al., "Acutely Traumatized Canine Ureter. Effects of Low Molecular Weight Dextran and Surfactant Pluronic F-68," Urology, vol. 3, No. 2, pp.190-194 (Feb. 1974).
Byars, N.E. et al., "Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity," Vaccine, vol. 5, pp. 223-228 (Sep. 1987).
Gaehtgens, P., et al., "Disaggregation of Human Red Blood Cells by Various Surface-Active Agents as Related to Changes of Cell Shape and Hemolysis", Act Heamat. vol. 53, pp. 82-89 (1975).
Grover, F.L., et al., "A Nonionic Surfactant And Blood Viscosity," Arch. Surg., vol. 106, pp. 307-310 (1973).
Grover, F.L., et al, "The Effect of Pluronic.RTM. F-68 On Circulatory Dynamics And Renal And Carotid Artery Flow During Hemorrhagic Shock," Journal of Surgical Research, vol. 17, pp. 30-35 (1974).
Hoie, J., et al., "Effects of Pluronic.RTM. F68, Poloralkol, On Vascular Resistance In Vivo," Journal of Surgical Research, vol. 11, pp. 515-517 (1971).
Hunter, R.L. et al., "Nonionic Block Coploymer Surfactants as Immunological Adjuvants: Mecanisms of Action and Novel Formulations," Immunological Adjuvants and Vaccines, ed. by Gregoriadis, G. et al., Plenum Publishing Corp., pp. 133-144 (1989).
Hunter, R.L. et al., "The Adjuvant Activity of Nonionic Block Polymer Surfactants. III. Characterization of Selected Biologically Active Surfaces," Scand. J. Immunol., vol. 23, pp. 287-300 (1986).
Hunter R. L. et al., "Adjuvant activity of non-ionic block copolymers. IV. Effect of molecular weight and formulation on titre and isotype of antibody," Vaccine, vol. 9, pp.250-256 (Apr. 1991).
Hymes, A.C., et al., "The Influence Of An Industrial Surfactant Pluronic.RTM. F-68, In The Treatment of Hemorrhagic Shock," Journal of Surgical Research, vol. 11, pp. 191-197 (1971).
Ketchum, L.D., et al. "Experimental Use Of Pluronic.RTM. F-68 In Microvascular Surgery," Plastic and Reconstructive Surgery, vol. 53, pp. 288-292 (1974).
Ketchum, L.D., "Pharmacological alterations in the clotting mechansim: Use in microvascular surgery," Journal of Hand Surgery, vol. 3, pp. 407-415 (1978).
Knize, D.M., et al., "Use of Antisludging Agents in Experimental Cold Injuries," Surgery, Gynecology & Obstetrics, vol. 129, pp. 1019-1026 (1969).
Lane, T.A., et al., "Reduction in the toxicity of a component of an artificial blood substitute by supercritical fluid fractionation," Transfusion, vol. 28, pp. 375-378 (1987).
Moore, A.R., et al, "Reduction Of Splenic Vascular Resistance During Profusion By Pluronic.RTM. F-68," Journal of Surgical Research, vol. 8, pp. 563-566 (1968).
Paton, B.C. et al. "The use of a nonionic detergent added to organ perfusates," Organ Perfusion and Preservation, ed. by Norman, J.C., Appleton-Century-Crofts, pp. 105-120 (1968).
Schmolka, I.R. et al., "Artificial Skin I. Preparation and Properties of Pluronic F-127 Gels for Treatment of Burns," J. Biomed. Mater. Res., vol. 6, pp. 571-582 (1972).
Snippe, H. et al., "Adjuvant Effect of Nonionic Block Polymer Surfactants in Humoral and Cellular Immunity," Int. Archs Allergy appl. Immun., vol. 65, pp. 390-398 (1981).
Takayama, K. et al., "Adjuvant activity of non-ionic block copolymers. V. Modulation of antibody isotype by lipopolysaccharides, lipid A and precursors," Vaccine, vol. 9, pp. 257-265 (Apr. 1991).
Vasko, K. A., et al., "Poloxalkol.RTM. (Pluronic F-68): A Priming Solution of Cardiopulmonary Bypass," Trans. Am. Soc. Artif. Int. Organs, 18, 526-531 (1972).
Williams, J.H. et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antiinfective compounds and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiinfective compounds and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiinfective compounds and methods of use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1620071

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.