Antiidiotypic monoclonal antibodies MK2-23 anti-melanomal antibo

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303877, 5303897, 5303911, 5303915, 935 15, 4241311, 4241381, 4241551, 4241781, 424 932, 536 2353, 4351722, 43524027, 435 7021, 435965, A61K 39395, C07K 1628, C07K 1642, C12N 516

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054930090

ABSTRACT:
The invention concerns murine antiidiotypic monoclonal antibodies which are the internal image of determinants recognized by a monoclonal antibody on high molecular weight-melanoma associated antigen (HMW-MAA), antibody derivatives, hybridoma cell lines secreting such antiidiotypic monoclonal antibodies, and processes for the preparation of such antiidiotypic monoclonal antibodies, of their derivatives and of the hybridoma cell lines. The murine antiidiotypic monoclonal antibodies are useful for the determination of antibodies directed against high molecular weight-melanoma associated antigen, for the modulation of the immune response to HMW-MAA and for the treatment of melanoma.

REFERENCES:
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