Antihypertensives containing polysaccharide peptidoglycan comple

Details Antihypertensives containing polysaccharide peptidoglycan comple Antihypertensives containing polysaccharide peptidoglycan comple

1990-06-22

1993-08-10

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

426656, 514322, 514395, A61K 3702, C07K 1504, C07K 1514

Patent

active

052349047

ABSTRACT:
The present invention relates to antihypertensives and food and drinks, containing as effective component polysaccharideglycopeptide complexes derived from cell wall of Gram positive bacteria (also referred to as peptidoglycan). The present invention provides extremely strong and safe antihypertensives and food and drinks, which may exert hypotensive effects if administered orally to spontaneous hypertensive rats and renal hypertensive rats at a single dose as low as 1 mg/kg.

REFERENCES:
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Hamada, O. et al., Chem. Abs., vol 71(1):945c, 1968.
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Campbell, J. et al., Biochemistry, 8(1):193-200, 1969.
Kushikata, Chem. Abs., vol 68, (11):48112u, 1967.
Verhoef, J., et al., Chem. Abs., vol. 101(21):189136s, 1983.
Verhoef, J., et al., Chem. Abs., vol 103(23):191164; 1985.
Osol (Editor), Remington's Pharmaceutical Sciences, Mach Publishing Co., 1980.

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