Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-06-13
1987-12-01
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546114, A61K 3144, C07D49504
Patent
active
047105062
ABSTRACT:
Novel thienopyridones with antihypertensive activity have the formula I, ##STR1## wherein the ring A represents an optionally substituted thiophene ring; m is 0 or 1; n is 0, 1 or 2; R is lower alkyl and R.sub.1 is lower alkyl.
The fused thieno-ring may carry one or two substituents.
Formula I encompasses thieno[3,2-b]pyridones, thieno[3,4-b]pyridones and thieno[2,3-b]pyridones.
Processes for preparing the novel thienopyridones and pharmaceutical compositions containing them are described. Pharmaceutically acceptable acid addition salts of the compounds of formula I are also described.
The thienopyridones of formula I are antihypertensive agents and are also indicated for use in treating heart failure and ischaemic heart disease.
REFERENCES:
patent: 3997545 (1976-12-01), Kuwada et al.
patent: 4302460 (1981-11-01), Davies et al.
patent: 4447435 (1984-05-01), Davies
Davies Roy V.
Fraser James
Dentz Bernard I.
Jiles Henry R.
The Boots Company PLC
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