Antihypertensive tetrapeptide amides

Details Antihypertensive tetrapeptide amides Antihypertensive tetrapeptide amides

1984-04-12

1985-04-09

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, C07C10352

Patent

active

045100853

ABSTRACT:
This invention relates to novel tetrapeptide adamantyl amides that are useful in the treatment of hypertension.

REFERENCES:
patent: 4273704 (1981-06-01), Mazur
Goodman & Gilman, The Pharmacological Basis of Therapeutics, (New York, 1975), Fifth Edition, Chaps. 26, 27, 28, 30, 33, 39, 40.
Poulsen, Burton, & Haber, "Competitive Inhibitors of Renin," Biochemistry, 12, 3877-3882 (1973).
Burton, Cody, Herd, & Haber, "Specific Inhibition of Renin by an Angiotensinogen Analog . . . ", Proc. Natl. Acad. Sci. USA, 77, 5476-5479 (1980).
Cody, Burton, Evin, Poulsen, Herd, & Haber, "A Substrate Analog Inhibitor of Renin that is Effective in Vivo", Biochem. Biophys. Res. Commun., 97, 230-235 (1980).
Burton, Poulsen, & Haber, "Competitive Inhibitors of Renin . . . ", Biochemistry, 14, 3892-3898 (1975).
Haas, Lewis, Scipione, & Koshy, "Micromethod for the Assay of Renin of Seven Species," Hypertension, 1, 112-117 (1979).
Eddy & Leimbach, "Synthetic Analgesics. II . . . ", J. Pharmacol. and Exp. Therap., 107, 385-393 (1953).

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