Antihypertensive pyridylguanidine compounds

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546306, A61K 3144, C07D21100

Patent

active

RE0312444

ABSTRACT:
The invention relates to a series of new compounds, to methods for preparing the compounds, to compositions containing said compounds which are useful in the human and veterinary medical practice, and to methods for treating patients suffering from certain illnesses with said compounds, the new compounds having the general formula I ##STR1## or the tautomeric forms thereof in which the R.sup.1 -substituted cyano-guanidyl radical is placed in the 2-, 3- or 4-position of the pyridine ring, and in which R.sup.1 stands for a straight or branched, saturated or unsaturated, aliphatic hydrocarbon radical having from 1 to 8 carbon atoms, a cycloalkyl or cycloalkenyl radical having from 3 to 7 carbon atoms, an aryl or an aralkyl radical, and R.sup.2 stands for hydrogen, halogen, hydroxy, lower alkyl or alkoxy radicals; and in the case of the present compounds containing one or more asymmetric carbon atoms, also the stereoisomers thereof and racemic mixtures of same; and salts of the compounds of formula I with nontoxic, pharmaceutically acceptable acids. The new compounds of the invention have surprisingly shown to be highly potent hypotensive compounds giving rise to a pronounced reduction of the blood pressure. They have a low toxicity and consequently a high therapeutic ratio.

REFERENCES:
patent: 3036083 (1962-05-01), Mull
patent: 3897444 (1975-07-01), Durant et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antihypertensive pyridylguanidine compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antihypertensive pyridylguanidine compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antihypertensive pyridylguanidine compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1561407

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.