Antihypertensive polyhalohydroxyisopropyl phenylalka(e)noic acid

Details Antihypertensive polyhalohydroxyisopropyl phenylalka(e)noic acid Antihypertensive polyhalohydroxyisopropyl phenylalka(e)noic acid

1982-03-10

1984-05-22

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424308, 424304, 560 17, 560 23, 560 62, 560 45, 260465D, C07C 69612, C07C 69618, A61K 31235

Patent

active

044501722

ABSTRACT:
Polyhalohydroxyisopropyl phenylalka(e)noic acid esters of alkylaminohydroxypropyloxyphenylalkyl alcohols, such as 2-(4-((2-hydroxy-3-(1-methylethylamino)-phenyl)ethyl 3-(4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl))benzene propanoate, are useful as antihypertensive agents. Preferred compounds give vasodilatory activity and reduced tachycardia.

REFERENCES:
patent: 3236894 (1966-02-01), England
patent: 3873600 (1975-03-01), Brandstrom et al.
patent: 3876802 (1975-04-01), Brandstrom et al.
patent: 4199597 (1980-04-01), Neustadt et al.
patent: 4311708 (1982-01-01), Manoury et al.

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