Antihypertensive neutral lipid

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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Details

260403, 514546, 560263, A61K 3122, A61K 3342

Patent

active

045956812

ABSTRACT:
The invention relates to the discovery of a class of neutral acetylated ether-linked glycerolipids having the capacity to lower blood pressure in warm-blooded animals. This physiological effect is structure sensitive requiring a long chain alkyl group at the sn-1 position and a short carbon chain acyl group (acetyl or propionyl) at the sn-2 position, and a hydroxyl group at the sn-3 position.

REFERENCES:
patent: 4329302 (1982-05-01), Hanahan et al.
Renooij et al., Biochimica et Biophysica Acta, vol. 663, (1981), pp. 545-556.

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