Antihypertensive isoindole derivatives

Details Antihypertensive isoindole derivatives Antihypertensive isoindole derivatives

1982-11-12

1985-01-22

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546200, 546223, A61K 31445, C07D40104

Patent

active

044951949

ABSTRACT:
Novel phthalimide intermediates are reduced to 5-sulfamoyl-6-halo-3-oxoisoindole compounds bearing a substituted 1-phenylalkyl-4-piperidinyl moiety as the isoindole N-substituent. Preferred compounds such as 6-chloro-2,3-dihydro-3-oxo-2-[1-(phenylmethyl)-4-piperidinyl]-1H-isoindole -5-sulfonamide exhibit diuretic and antihypertensive properties.

REFERENCES:
patent: 3579524 (1971-05-01), Van Dyke
Topliss, J., J. Med. Chem., 15, (10), 1006, (1972).
Cornish, E., et al., J. Pharm. Pharmac., 18, 65-80, (1966).
Chemical Abstracts, 81: 58265d, (1974), [Suzuki et al., Nippon Yakurigaku Zasshi, 1972, 68, (3), 276-89].
Chemical Abstracts, 90: 97589t, (1979), [Himori et al., Jpn. J. Pharmacol., 1978, 28, (6), 811-18].

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