Antihypertensive esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycar

Details Antihypertensive esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycar Antihypertensive esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycar

1985-05-14

1987-01-06

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546321, C07D21190, A61K 31455

Patent

active

046347127

ABSTRACT:
##STR1## Esters I (Ar=3-nitrophenyl or 2,3-dichlorophenyl, A=C.sub.2 -C.sub.6 alkylene, R=C.sub.1 -C.sub.6 alkyl optionally C.sub.1 -C.sub.6 alkoxy monosubstituted, R.sub.1 =C.sub.1 -C.sub.4 alkyl) have antihypertensive activity and are effective against coronary heart diseases. They are prepared starting from the aldehyde ArCHO and esters of acetoacetic acid and 3-aminocrotonic acid. Pharmaceutical preparations containing them are also described.

REFERENCES:
patent: 4423052 (1983-12-01), Araki et al.

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