Antihypertensive diuretic combination composition and associated

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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Details

424251, 424 20, 424361, 264109, 264113, 264118, A61K 31505, A61K 3154

Patent

active

044447698

ABSTRACT:
A novel combination pharmaceutical composition is described, together with a method for making the same, wherein the pharmaceutically active ingredients are separately milled and then formed into separate granules, and only thereafter blended together to form the combination composition. The method for achieving this novel combination composition is also described. In particular, a novel combination composition of triamterene and hydrochlorothiazide having improved bioavailability and novel effectiveness to prevent or eliminate hypokalemic side effects is also described.

REFERENCES:
patent: 3081230 (1963-03-01), Weinstock et al.
Marvola et al., Chem. Abs. 96:91566k.
Reyes et al., Chem. Abs. 97:174735m.
Roehm, Pharma. Chem. Abs. 89:30766j.

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