Antihypertensive dihydropyridine-5-phosphonic acid cyclic esters

Details Antihypertensive dihydropyridine-5-phosphonic acid cyclic esters Antihypertensive dihydropyridine-5-phosphonic acid cyclic esters

1984-09-26

1986-03-18

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 89, 546 21, 544337, C07F 958, A61K 31675

Patent

active

045769346

ABSTRACT:
A compound of the formula: ##STR1## where X is hydrogen, nitro, trifluoromethyl, fluorine, chlorine, bromine or iodine; A is 1,3-propylene or 1,4-butylene which may be substituted by C.sub.1 -C.sub.3 alkyl, R is C.sub.1 -C.sub.4 alkyl, --Y--N(R.sup.1)(R.sup.2) or ##STR2## where each of R.sup.1, R.sup.2 and R.sup.3, which may be the same or different are hydrogen, C.sub.1 -C.sub.6 alkyl, or aralkyl, and Y is C.sub.2 -C.sub.6 alkylene, and Me is methyl, or its pharmaceutically acceptable salt. These compounds have utility as anti-hypertensive agents and coronary or peripheral vasodilators.

REFERENCES:
patent: 3485847 (1969-12-01), Bossert
patent: 4393070 (1983-07-01), Sato et al.
patent: 4532248 (1985-07-01), Franckowiak et al.
patent: 4535073 (1985-08-01), Kimura et al.

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