Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-04-17
1993-08-31
Lilling, Herbert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 9, 514 10, 530317, 435 711, A61K 3702, C07K 754
Patent
active
052409104
ABSTRACT:
Novel cyclic depsipeptides derived from a culture of Microbispora are antagonists of the receptor for endothelin, a potent vasoconstrictor, and are thus useful in treating cardiovascular disorders. Endothelin has other physiological effects, and the endothelin receptor antagonists of the present invention thus also have other therapeutic uses. The compounds are cyclical depsipeptides of N-(pyrrol-2-carboxy) - L-phe, D-allo-Thr, D-Phe, D-Ala, D- or L-dihydroxyphenyl-Gly, and D-dihydroxyphenyl-Gly.
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Lam Yiu-kuen T.
Williams, Jr. David L.
Zink Deborah L.
Ayler Sylvia A.
Daniel Mark R.
DiPrima Joseph F.
Lilling Herbert J.
Merck & Co. , Inc.
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