Antihypertensive compound and method of use thereas

Details Antihypertensive compound and method of use thereas Antihypertensive compound and method of use thereas

1992-04-23

1993-06-08

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514301, C07D40501, A61K 3141

Patent

active

052181251

ABSTRACT:
Fermentation of the microorganism Streptomyces sp. MA6966 (ATCC 55293) in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields a new compound hydroxylated in the 2-butyl group which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

REFERENCES:
Ralph A. Stearns et al., Drug Metabolism and Disposition, Vol. 20, No. 2, pp. 281-287 (1992).

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