Antihypertensive compositions and use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514649, 514929, A61K 31135

Patent

active

052122042

ABSTRACT:
This invention concerns antihypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein J is an organic or inorganic moiety, M.sup.+x is a pharmaceutically acceptable cation and the compound decomposes under physiological conditions to release nitric oxide (NO).

REFERENCES:
patent: 2635978 (1953-04-01), Massengale
patent: 2954314 (1960-09-01), Metzger et al.
patent: 3309373 (1967-03-01), Danzig
Palmer et al. Nature 327, 524-526, 1987.
Kruszyna et al. Toxicology and Applied Pharmacology 91, 429-438, 1987.
Ignarro the FASEB Journal 3, 31-36, 1989.
Ignarro et al. J. of Pharmacology & Experimental Theraputics 218(3), 739-749, 1981.
Alston et al. J. Biol. Chem. 260(7), 4069-4074, 1985.
Kubrina et al. Izvestiia Akademii Nauk SSSR Seriia Biologicheskaia 6, 844-850, 1988.
Drago "Free Radicals in Inorganic Chemistry", No. 36, Advances in Chemistry Series, Amer. Chem. Soc., Wash. DC, 1962, pp. 143-149.
Wiersdorff et al. Chemical Abstracts 77:48034f, 1972.
Fujitsuka et al. Chemical Abstracts 82: 31108p, 1975.
World Patents Index Acc. No.: 80-59226c/34 JP 87017561 B (Apr. 18, 1987), abstracts of Jap. Patent.
"Pharmaceutics and Pharmacy Practice", eds Banker and Chalmers, J. B. Lippincott Co., Philadelphia, 1982, pp. 238-250.
ASHP "Handbook on Injectable Drugs" 4th ed., Trissel, pp. 622-630.
A. F. Vanin et al., Chem. Abstract 113:224354h (1990).
A. F. Vanin et al., Biokhimiya (Moscow) vol. 55, No. 2, pp. 1408-1413 (1990), with an English language Abstract.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antihypertensive compositions and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antihypertensive compositions and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antihypertensive compositions and use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-804792

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.