Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1975-04-16
1976-12-21
Drezin, Norman A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
424263, A61K 31455
Patent
active
039989550
ABSTRACT:
Pyridines of the formula I ##STR1## wherein R.sub.1 is free hydroxyl, lower alkoxy, cycloalkoxy, amino-lower alkoxy or lower alkoxy-lower alkoxy, free amino, hydroxyamino, lower alkyleneamino, oxa-, aza- or thia-lower alkyleneamino or mono- or di-lower alkylamino, R.sub.2 is oxygen or sulphur, R.sub.3 and R.sub.4 are each alkoxy, free amino, mono- or di-lower alkylamino, lower alkyleneamino, oxa-, aza- or thia-lower alkyleneamino, halogen or free hydroxyl, and either R.sub.3 or R.sub.4 can be hydrogen, and alk is an alkyl group with 3-10 carbon atoms, and their N-oxides, and salts are useful as dopamine-.beta.-hydroxylase inhibitors.
REFERENCES:
patent: 3862159 (1975-01-01), Umezawa et al.
Markees et al., Chemical Abstracts 51:2775-2777, 1/10/57.
Cutting, Handbook of Pharmacology, 4th Edition, (1969) pp. 286-287.
Egli Christian
Eichenberger Kurt
Hedwall Phyllis Roberta
Kuhnis Hans
Ciba-Geigy Corporation
Drezin Norman A.
Groeger Theodore O.
Kolodny Joseph G.
Maitner John J.
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