Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1982-03-08
1985-10-29
Jiles, Henry R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
549439, 549480, 549495, C07C153017, C07D31766
Patent
active
045499926
ABSTRACT:
Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are independently hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,
n is an integer from 0 to 4 inclusive,
M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycyclo-alkyl-alkyl, aryl, aryalkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, dialkylaminoalkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused hetero-aryl-cycloalkyl, or fused heteroaryl-cycloalkyl-alkyl,
Y is hydroxy, alkoxy, amino, or substituted amino, amino-alkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, and
R.sub.7 is a group of the formula ##STR2## wherein X is a branched alkane or cycloalkyl; and where Y is hydroxy their non-toxic, pharmaceutically acceptable alkali metal, alkaline earth metal, and amine salts.
The compounds of this invention and their salts possess antihypertensive and angiotensin converting enzyme inhibitory activity.
REFERENCES:
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patent: 4091024 (1978-05-01), Ondetti
patent: 4116962 (1978-09-01), Ondetti et al.
patent: 4256761 (1981-03-01), Suh et al.
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Schwab Alfred
Skiles Jerry W.
Suh John T.
Williams Bruce E.
Jiles Henry R.
USV Pharmaceutical Corp.
Whittenbaugh Robert C.
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