Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-09-12
1985-11-19
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548305, 564 51, A61K 31415, C07D23526
Patent
active
045542872
ABSTRACT:
7-[2-Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones are prepared by oxidative cyclization of a urea, followed by removal of protective groups. The compounds are D.sub.2 -agonists and, thereby, have anti-hypertensive activity. A species of the group is 7[2-N,N-di-n-propylamino)ethyl]-4-hydroxyl-1,3-benzimidazol-2-one.
REFERENCES:
patent: 4070478 (1978-01-01), Talaty et al.
patent: 4314944 (1982-02-01), Huffman et al.
patent: 4367235 (1983-01-01), Ross et al.
Stringer Orum D.
Weinstock Joseph
Edgerton William H.
Foggio Richard D.
Lourie Alan D.
Schwartz Richard A.
SmithKline Beckman Corporation
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