Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-06-26
1987-04-21
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546153, 544128, 548252, A61K 3141, C07D40104
Patent
active
046597182
ABSTRACT:
Novel quinolones of formula I ##STR1## and pharmaceutically acceptable acid addition salts thereof in which the dotted line between positions 2 and 3 of the quinolone ring represents an optional bond, R is hydrogen, 1-methyl or 2-lower alkyl; R.sub.1 is lower alkyl; R.sub.2 is hydrogen, halo, lower alkyl, lower alkoxy, trifluoromethyl, cyano, difluoromethoxy, methylsulphinyl, phenylsulphinyl or the group --NR.sub.4 R.sub.5 or the N-oxide thereof wherein R.sub.4 and R.sub.5, which may be the same or different, are lower alkyl or, together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or morpholino radical; and R.sub.3 is hydrogen, fluoro, lower alkyl or lower alkoxy provided that, when R.sub.3 is lower alkoxy, R.sub.2 is other than lower alkoxy have utility as antihypertensive agents. Processes for preparing the quinolones and pharmaceutical compositions containing them are disclosed.
REFERENCES:
patent: 4035368 (1977-07-01), Erickson
patent: 4259437 (1981-03-01), Webb
patent: 4302460 (1981-11-01), Davies
patent: 4442109 (1984-04-01), Davies
patent: 4474787 (1984-10-01), Cairns
Erickson et al., J. of Medicinal Chemistry, 22(7), p. 816 (1979).
Gilis et al., Eur. J. Med. Chem., 15, No. 6, pp. 499-502 (1980).
Kim. J. Hetercyclic Chem., 18, pp. 1393-1397 (1981).
Davies Roy V.
Green Richard D.
Benson Robert
Nucker Christine M.
The Boots Company PLC
LandOfFree
Antihypertensive 3-tetrazoyl-4-quinolones does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antihypertensive 3-tetrazoyl-4-quinolones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antihypertensive 3-tetrazoyl-4-quinolones will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-752145